23 If SDs were not provided, we calculated them from standard

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pandora bracelets When necessary, means and measures of dispersion were approximated from figures in the reports.Statistical analysisWe used an extension of multivariable Bayesian hierarchical random effects models for mixed multiple treatment comparisons with minimally informative prior distributions.20 21 It fully preserves the comparison of randomised treatments within each trial while combining all available comparisons between treatments and accounts for multiple comparisons within a trial when there are more than two treatment arms.22 For the analysis of effect sizes of pain, the model included random effects at the level of trials and time points. It accounted for the correlation of outcome data reported at different time points within a trial and allowed the estimation of the variance of treatment effects between trials (2). Effect sizes were calculated by dividing the differences in mean values between treatment groups in a time window by the median pooled standard deviation (SD) observed across all time points in a trial.23 If SDs were not provided, we calculated them from standard errors or confidence intervals as described elsewhere.10 24 An effect size of 0.20 SD units suggests an overlap in the distributions of reported pain scores in the experimental group with pain scores in placebo group in 85% and can be considered a small difference between experimental and control group.9 23 An effect size of 0.50 indicates an overlap in about 67% and can be considered a moderate difference https://www.pandoratopp.com/, whereas 0.80 suggests an overlap in 53% and is considered a large difference.9 23To allow intuitive interpretation of pooled effects pandora essence, we back transformed effect sizes to differences on a 10 cm visual analogue scale on the basis of a median pooled SD of 2.5 cm found in large scale osteoarthritis trials that assessed pain on a 10 cm visual analogue scale.12 We prespecified a minimal clinically important difference of 0.37 SD units, corresponding to 0.9 cm on a 10 cm visual analogue scale pandora bracelets.